Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of cas:820211-82-3:tiprelestat in China, also supports custom service. Welcome to wholesale bulk high quality cas:820211-82-3:tiprelestat from our factory. Contact us for more details.
| CAS:820211-82-3:Tiprelestat | |
| Tiprelestat is a highly selective neutrophil elastase (NE) inhibitor. It competitively binds to the enzyme active pocket and blocks elastase degradation of extracellular matrix and tissue proteins, alleviating inflammation-mediated tissue damage. Applied in mechanism research and drug development of inflammatory diseases such as acute lung injury, COPD and cystic fibrosis. | |
| 95% / 98% / 99% | |
| C₂₅H₃₂N₄O₇S | |
| 532.61 |
| Peptidomimetic small-molecule inhibitor with sulfonamide structure |
| Function Tags (comma-separated) | ||||||||
| Tiprelestat; Elastase inhibitor; ONO-5046; CAS 820211-82-3 | High NE selectivity,Anti-tissue damage,Acute lung injury study,COPD study,Protease inhibitor,Anti-inflammatory tissue protection | C₂₅H₃₂N₄O₇S | 532.2 | 532.61 | Peptidomimetic small-molecule inhibitor |
| Long-term Storage Conditions | Short-term Storage Conditions | ||||
| SML-TIP001 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid high temperature and humidity | Solid powder stable for 3 years at 2-8℃ sealed and dry; stock solutions prepared in DMSO | Stable for 1 month at 4℃ in dark; stable for 3 months at -20℃ in aliquots. **Poor water solubility, DMSO or acetonitrile required for solubilization**. Excellent solid stability; solution can be stored short-term at room temperature. Sensitive to acid-base conditions | Stable for over 3 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| SML-TIP001 | Tiprelestat is a structurally optimized peptidomimetic elastase inhibitor. It binds with high affinity and high selectivity to the active center pocket of neutrophil elastase, and inhibits enzymatic degradation of extracellular matrix proteins such as elastin, collagen and fibronectin by competitively blocking substrate binding, thereby reducing neutrophil-mediated tissue damage and edema at inflammatory sites. This molecule has much higher selectivity for neutrophil elastase than other serine proteases, with low off-target side effects. In models such as acute lung injury, chronic obstructive pulmonary disease, cystic fibrosis and ischemia-reperfusion injury, it can significantly reduce tissue destruction and improve organ function. It serves as a classic tool compound for serine protease function research, inflammatory tissue damage mechanism analysis and novel protease inhibitor drug development. |
Popularni tagovi: cas:820211-82-3:tiprelestat, China cas:820211-82-3:tiprelestat manufacturers, suppliers, factory, 137525-51-0, CAS 129954 34 3, CAS 1566590 77 9, CAS 2381089 83 2, Melanotan II, Selank
